R'MES is a tool to find motifs with a significantly unexpected frequency in biological sequences
The main question R'MES addresses is "does this motif occur in that biological sequence with an expected frequency?" In other words, can we observe it so many times, or so few times, just by chance? Usually, when the answ er is no, such a motif is a candidate to have a particular biological meaning; only a candidate: statistical significance is not equivalent to biological significance.
Langages C et C++